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AmplideX® PCR/CE C9orf72 Kit

AmplideX® PCR/CE C9orf72 Kit

CODE 49581
DESCRIPTION AmplideX® PCR/CE C9orf72 Kit

AmplideX® PCR/CE C9orf72 Kit

C9orf72 main web image smallThe AmplideX PCR/CE C9orf72 Kit (RUO) is a research product for the detection of GGGGCC repeats in the C9orf72 gene. These reagents provide a single-tube PCR approach based on a Repeat-Primed PCR (RP-PCR) design to profile repeat sequences in the C9orf72 gene.

 

 

 

Features & Benefits

Asuragen has established the market-leading technology for the reliable amplification and analysis of CGG triplet repeats in the FMR1 gene. The AmplideX PCR/CE C9orf72 Kit (RUO) is an expansion of this technology into the neurogenetics space. The kit provides clinical and pharmaceutical researchers with a reliable and reproducible method for high-resolution genotyping of hexanucleotide repeat expansions in the C9orf72 gene, which is of increasing interest in frontotemporal dementia (FTD) – the second most common form of early onset dementia after Alzheimer’s Disease – and amyotrophic lateral sclerosis (ALS).

Reduced Complexity
Analysis of the C9orf72 gene has been simplified through:

  • Implementation of proprietary 2-in-1 PCR solution for amplifying GC-rich regions
  • A single sourced kit consisting of all PCR reagents needed for C9orf72 repeat amplification
  • Streamlined workflow with minimal hands-on time

Optimized Workflow
Valuable operator hands-on time has been significantly reduced through:

  • Single PCR reaction for both sizing and screening
  • Direct injection of PCR products (no PCR clean up) to Capillary Electrophoresis platforms
  • Decreased need for Southern blot analysis

Quality Performance
Performing C9orf72 analysis with greater sensitivity and accuracy:

  • Five-fold improvement in length of alleles sized: accurate sizing up to 145 repeats
  • Detection of alleles greater than 145 repeats
  • Reveal low-level mosaicism and minor alleles

Analytic Characteristics

Analytical characteristics of AmplideX PCR/CE C9orf72 Kit:

  • Accurately sizes up to 145 repeats (Figure 1)
  • Detects alleles >145 repeats (Figure 2)
  • Resolves zygosity (Figure 3)




Download AmplideX C9orf72 - Brochure.pdf

AmplideX® PCR/CE C9orf72 Kit - Asuragen Molecular Products

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p.iva 12585340156
info@diametra.com

HEADQUARTER, R & D and MANUFACTURING

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T +39.0742.24.851 +39.0742.30.19.29
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Management and Coordination : Immunodiagnostic Systems (IDS) Ltd, Boldon-UK
 
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