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AmplideX PCR/CE C9orf72 Kit

AmplideX PCR/CE C9orf72 Kit

CODE 49581
DESCRIPTION AmplideX PCR/CE C9orf72 Kit

 

C9orf72 main web image small

The AmplideX PCR/CE C9orf72 Kit (RUO) is a research product for the detection of GGGGCC repeats in the C9orf72 gene. These reagents provide a single-tube PCR approach based on a Repeat-Primed PCR (RP-PCR) design to profile repeat sequences in the C9orf72 gene.

 
 
 
 
Features & Benefits
 
Asuragen has established the market-leading technology for the reliable amplification and analysis of CGG triplet repeats in the FMR1 gene. The AmplideX PCR/CE C9orf72 Kit (RUO) is an expansion of this technology into the neurogenetics space. The kit provides clinical and pharmaceutical researchers with a reliable and reproducible method for high-resolution genotyping of hexanucleotide repeat expansions in the C9orf72 gene, which is of increasing interest in frontotemporal dementia (FTD) – the second most common form of early onset dementia after Alzheimer’s Disease – and amyotrophic lateral sclerosis (ALS).
 
 
Reduced Complexity

Analysis of the C9orf72 gene has been simplified through:
·         Implementation of proprietary 2-in-1 PCR solution for amplifying GC-rich regions
·         A single sourced kit consisting of all PCR reagents needed for C9orf72 repeat amplification
·         Streamlined workflow with minimal hands-on time
 
 
Optimized Workflow

Valuable operator hands-on time has been significantly reduced through:
·         Single PCR reaction for both sizing and screening
·         Direct injection of PCR products (no PCR clean up) to Capillary Electrophoresis platforms
·         Decreased need for Southern blot analysis
 
 
Quality Performance

Performing C9orf72 analysis with greater sensitivity and accuracy:
·         Five-fold improvement in length of alleles sized: accurate sizing up to 145 repeats
·         Detection of alleles greater than 145 repeats
·         Reveal low-level mosaicism and minor alleles
 
 
Analytic Characteristics
 
Analytical characteristics of AmplideX PCR/CE C9orf72 Kit:
·         Accurately sizes up to 145 repeats
·         Detects alleles >145 repeats
·         Resolves zygosity




Download AmplideX C9orf72 - Brochure.pdf

AmplideX PCR/CE C9orf72 Kit - Asuragen Molecular Products

DiaMetra srl Unipersonale

p.iva 12585340156
info@diametra.com

HEADQUARTER, R & D and MANUFACTURING

Via Pozzuolo, 14 - 06038 Spello - Perugia Italy
T +39.0742.24.851 +39.0742.30.19.29
F +39.0742.31.61.97
Management and Coordination : Immunodiagnostic Systems (IDS) Ltd, Boldon-UK
 
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