Features & Benefits
AmplideX PCR/CE FMR1 Reagents have created an easy-to-use, accessible, high performance method for laboratories to reliably analyze CGG repeats and detect interrupting AGG sequences in the FMR1 gene.
Reduced Complexity
Ease-of-analysis of the FMR1 gene has been simplified through:
· Implementation of proprietary PCR solution for amplifying GC-rich regions
· Automation of result calling using AmplideX PCR/CE FMR1 Reporter
Optimized Workflow
Valuable operator hands-on time has been significantly reduced through:
· Direct injection of PCR products (no PCR clean up) in to Capillary Electrophoresis platforms
· Decreased need for Southern blot analysis (up to 50 fold)
· End-to-end solution for FMR1 analysis including all necessary reagents and software
Quality Performance
Performing FMR1 Analysis with Greater Sensitivity and Accuracy:
· Detection of all allele expansions, including low abundance full mutation size mosaics with up to at least 1300 CGG repeats
· Up to 875 fold more sensitive than Southern blot1
· Resolution of female homozygous and heterozygous samples and indication of interrupting AGG sequences
· Proven performance as indicated by more than 30 peer reviewed publications
Analytical Characteristics of AmplideX PCR/CE FMR1 Reagents:
· Detects all alleles including low abundance full mutations
· Accurately sizes any repeat up to 200 CGG repeats
· Resolves female zygosity
· Detects presence of AGG interruptions
Prodotti per il mercato Italiano