AmplideX PCR/CE SMN1 Kit

The AmplideX PCR/CE SMN1 Kit provides a rapid, robust, and reliable method for the quantification of SMN1 exon 7 copy number from whole blood and buccal samples.  With its streamlined PCR/CE workflow, rapid turnaround time, and automated results reporting software, the assay provides a simple and scalable SMN1 solution for all laboratories.

Features & Benefits

AmplideX technology has become widely established for the detection and quantification of repeat expansions in a number of genes, including FMR1, C9orf72, and DMPK.  With the AmplideX PCR/CE SMN1 Kit, this approach is applied to copy number resolution, allowing SMN1 exon 7 copy number to be estimated in under four hours using readily available laboratory equipment.

Reduced Complexity

·         Similar workflow to the AmplideX FMR1 kit eases implementation and testing

·         Scalable design allows for high-throughput testing

·         Automated analysis objectively reports copy number

Optimized Workflow

·         A simplified workflow compared to alternative methods

·         Fully kitted solutions with fewer QC and pipetting steps

·         DNA to data in under four hours with only 45 minutes of hands-on-time

Quality Performance

·         Ability to differentiate between 0, 1, 2, 3 and > 3 copies

·         Robust, reliable results with non-overlapping ratios for each copy number output

·         Concordance with previously characterized samples

Analytical characteristics of AmplideX PCR/CE SMN1 Kit:

·         Excellent concordance with previously characterized clinical samples

·         Consistent results compared to other commercially available methods

·         Automated results reporting via AmplideX Reporter software