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AmplideX PCR/CE SMN1/2 Plus Kit

AmplideX PCR/CE SMN1/2 Plus Kit

CODE A00050
Copy number variations in SMN1 and SMN2 are, respectively, associated with the onset and severity of spinal muscular atrophy (SMA), a debilitating and life-threatening illness of the central nervous system.
Recent studies have demonstrated that transmission risk and disease severity may be impacted by the presence of additional variants, such as SMN1 gene duplication events and disease modifier in SMN2.
The AmplideX PCR/CE SMN1/2 Plus Kit revolutionizes the analysis of these two genes by delivering comprehensive results in less than four hours.
Powered by AmplideX technology, the assay accurately quantifies SMN1 and SMN2 exon 7 copy number and also detects SMN1 gene duplication and SMN2 disease modifier variants – all from a single reaction. The assay shares a common workflow with other assays in the AmplideX product portfolio and is optimized for use on widely established laboratory equipment.
Reduced Complexity
  • Multiplexed, scalable design allows analysis of single-nucleotide variants, small indels, and copy-number changes from a single PCR reaction
  • Assay-specific software automates variant calls and streamlines data analysis
Optimized Workflow
  • DNA-to-data in less than four hours with only 60 minutes of hands-on-time
  • Optimized for use on commonly installed CE equipment
  • Fully-kitted solution sourced from a single vendor
Quality Results
  • Ability to differentiate between 0, 1, 2, 3 and ≥4 copies for both SMN1 and SMN2
  • Automated variant and copy-number genotyping
  • Accuracy demonstrated through comparisons with multiple orthogonal method
Analytical Characteristics
  •  Automated reporting of SMN1/2 copy number and variant detection via AmplideX Reporter Software
  • DNA to data in less than four hours – all from a single PCR reaction
  • Excellent concordance of SMN1 and SMN2 copy number results to sites’ in-house     methods for over 500 replicates
  • High assay specificity permits detection of SMN1–SMN2 hybrid peaks, including those resulting from gene conversion events
  • 100% agreement between Sanger sequencing and PCR/CE SMN1/2 Plus Kit for detection of SMN1 gene duplication and SMN2 disease modifier variants 

Download AmplideX SMN1_2 Plus Brochure.pdf

AmplideX PCR/CE SMN1/2 Plus Kit - Asuragen Molecular Products

DiaMetra srl Unipersonale

p.iva 12585340156


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T +39.0742.24.851 +39.0742.30.19.29
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Management and Coordination : Immunodiagnostic Systems (IDS) Ltd, Boldon-UK
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